| 
            Only notified under the "contained use" procedure. Dossier submitted on 20/08/2018.           | 
                  
            A Phase I/II study of the safety and efficacy of a single dose of autologous CRISPR-Cas9 modified CD34+ human hematopoietic stem and progenitor cells in subjects with severe sickle disease           | 
                  
                  
            Humans           | 
                  
            Modified cells expressing Hemoglobin F (HbF)           | 
              
          
                  | 
            Only notified under the "contained use" procedure. Dossier submitted on 05/07/2005.           | 
                  
            A multicenter, randomized, double-blind, placebo-controlled study evaluating the efficacy of Biobypass (ADGVVEGF121.10NH) delivered by NOGATM-guided/MYOSTARTM catheter in "no option" patients with class II-IV stable angina           | 
                  
                  
            Humans           | 
                  
            human VEGF121           | 
              
          
                  | 
            Only notified under the "contained use" procedure. Dossier submitted on 13/10/2000.           | 
                  
            A phase III open-label, comparative, multicentre trials to test the concept of durable virologic suppression in subjects with primary HIV-1 infection after intensive induction of quadruple HAART followed by double-blind randomization to HIV vaccination wi           | 
                  
                  
            Humans           | 
                  
            vCP-1452           |