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            Only notified under the "contained use" procedure. Dossier submitted on 02/12/2019.           | 
                  
            A multicentre, open-label, single ascending dose, dose-ranging, phase I/Iia study to evaluate the safety and tolerability of an autologous antigen-specific chimeric antigen receptor T regulatory cell therapy (TX200-TR101) in living donor renal transplant            | 
                  
                  
            Humans           | 
                  
            chimeric antigen receptor specific to the donor HLA A*2           | 
              
          
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            B/BE/12/BVW2           | 
                  
            Clinical trial evaluating the safety and efficacy of intracoronary administration of MYDICAR (AAV1/SERCA2a) in subjects with heart failure           | 
                  
                  
            Humans           | 
                  
            Human SERCA2a:CA++ pump involved in the regulation of heart contraction/relaxation cycle           | 
              
          
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            B/BE/11/V3           | 
                  
            Evaluation of the safety and efficacy of the vaccine PB-116 in the control of porcine pleuropneumonia caused by Actinobacillus pleuropneumoniae           | 
                  
                  
            pigs           | 
                  
            no new genes but deletion of a segment of gene A from which depends the haemolytic activity of the pathogen           |