A multinational, open-label, dose escalation Phase I/II study to assess the safety and clinical activity of multiple administrations of NKR-2 in patients with different metastatic tumor types

Date receipt dossier

EudraCT number

2016-003312-12

Company / Sponsor

Celyad

Phase

I

Treated organism

Humans

Indication category

Cancer therapy

Disease

cancer

Therapeutic approach

Immunotherapy

Genetic modification

NKG2D-chimeric antigen receptor

Method of transfer of nucleic acid of interest

Moloney Murine Leukemia Virus

Administered biological material

Autologous T-cells retrovirally transduced with a chimeric antigen receptor based on the NKG2D receptor

Route of administration

Intravenous

Locations in Belgium

UZ Gent, Grand Hôpital de Charleroi

Nr of subjects

24 participants

Foreseen duration

4 years

Type of procedure

Contained use only

Current status

Authorized

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